Diagnostic and therapeutic challenges of primary cutaneous lymphomas.

Primary cutaneous lymphomas represent a broad spectrum of distinct entities with multiple clinical and pathologic presentations, prognosis, and treatment approaches. Given their rarity and heterogeneity, these entities represent diagnostic and therapeutic challenges, thus requiring a multidisciplinary approach and expertise to ensure appropriate diagnosis and management. According to the new World Health Organization (WHO) classification, primary cutaneous CD30-positive lymphoproliferative disorders (CD30+ LPD) are the second most common group of cutaneous T-cell lymphomas, accounting for approximately 30% of all cases.[1] This group includes primary cutaneous anaplastic large-cell lymphoma (ALCL), lymphomatoid papulosis (LyP), and borderline cases.